| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10599333 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
A series of saucerneol B derivatives 2a-i were prepared for evaluating their acyl-CoA: cholesterol acyltransferase inhibitory activities. Compounds 2a-g showed more specificity of hACAT-1 than hACAT-2. Saucerneol B (1) exhibited strong cholesterol-lowering effect in high cholesterol-fed mice.
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Authors
Tae-Sook Jeong, Kyung Soon Kim, Hana Yu, Mi Jeong Kim, Kyung-Hyun Cho, Yang-Kyu Choi, Hyoung-Chin Kim, Ho-Yong Park, Woo Song Lee,