| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10599339 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
Novel cyclohexadienes have been identified as potent and specific IKCa-channel blockers. In this communication we describe their synthesis as well as their chemical and biological properties. A selected derivative distributes well into brain and reduces the infarct volume, intracranial pressure as well as the water content in a rat subdural hematoma model of traumatic brain injury after iv administration.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Klaus Urbahns, Siegfried Goldmann, Jochen Krüger, Ervin Horváth, Joachim Schuhmacher, Rolf Grosser, Volker Hinz, Frank Mauler,