Article ID Journal Published Year Pages File Type
10759671 Biochemical and Biophysical Research Communications 2013 6 Pages PDF
Abstract
► We report the block of the β-adrenoceptor-activated cardiac CFTR Cl− current by Ni2+. ► Extracellular Ni2+ inhibits the current activated by β1-adrenoceptors in a concentration-dependent manner. ► The action of Ni2+ is insensitive to β2-blockade. ► Ni2+ does not affect the β-adrenoceptor-activated current from the intracellular side. ► The data are consistent with an action of Ni2+ at the β1-adrenoceptor from the external side.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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Nickel inhibits β-1 adrenoceptor mediated activation of cardiac CFTR chloride channels
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