| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10761843 | Biochemical and Biophysical Research Communications | 2012 | 5 Pages |
Abstract
⺠The biological function of TrkB-Shc in response to BDNF treatment is assessed. ⺠We found TrkB-Shc protein levels were decreased when cells were exposed to BDNF. ⺠TrkB-Shc dampens TrkB-TK+ activity and moreso following BDNF exposure. ⺠TrkB-Shc protein is more stable following BDNF exposure. ⺠TrkB-Shc may regulate BDNF-stimulated TrkB-TK+ activity by increasing its degradation.
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Authors
Jenny Wong, Brett Garner,