Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10795200 | Biochimica et Biophysica Acta (BBA) - Bioenergetics | 2016 | 39 Pages |
Abstract
We noticed that in menaquinone-reducing complexes I, less energy is available for ion translocation, compared to ubiquinone-reducing complexes I. Therefore, we hypothesized that menaquinone-reducing complexes I perform Na+/H+ antiporter activity in order to achieve the stoichiometry of 4H+/2eâ. In agreement, the organisms that use ubiquinone, a high potential quinone, would have kept such Na+/H+ antiporter activity, only operative under determined conditions. This would imply a physiological role(s) of complex I besides a simple “coupling” of a redox reaction and ion transport, which could account for the sophistication of this enzyme. This article is part of a Special Issue entitled Respiratory complex I, edited by Volker Zickermann and Ulrich Brandt.
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Authors
Paulo J. Castro, Andreia F. Silva, Bruno C. Marreiros, Ana P. Batista, Manuela M. Pereira,