Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10795273 | Biochimica et Biophysica Acta (BBA) - Bioenergetics | 2016 | 42 Pages |
Abstract
Succinate is an important metabolite at the cross-road of several metabolic pathways, also involved in the formation and elimination of reactive oxygen species. However, it is becoming increasingly apparent that its realm extends to epigenetics, tumorigenesis, signal transduction, endo- and paracrine modulation and inflammation. Here we review the pathways encompassing succinate as a metabolite or a signal and how these may interact in normal and pathological conditions.1
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Authors
Laszlo Tretter, Attila Patocs, Christos Chinopoulos,