Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10795476 | Biochimica et Biophysica Acta (BBA) - Bioenergetics | 2014 | 12 Pages |
Abstract
Our results show that functional maturation of oxidative phosphorylation in mitochondria is completed much earlier than efficient feedback regulation is established between mitochondria and ATPases via creatine kinase system. These changes are accompanied by significant remodeling of regular intermyofibrillar mitochondrial arrays aligned along the bundles of βII-tubulin. Additionally, we demonstrate that formation of regular arrangement of mitochondria is not sufficient per se to provide adult-like efficiency in metabolic feed-back regulation, but organized tubulin networks and reduction in mitochondrial outer membrane permeability for ADP are necessary as well. In conclusion, cardiomyocytes in rat heart become mature on the level of intracellular architecture and energy metabolism at the age of 3 months.
Keywords
RCIIMSMtCKFFAOXPHOSVDACANTVmaxFree fatty acidsadenine nucleotide translocatortubulinDevelopmentBioenergeticsRespiratory control indexmitochondrial outer membraneOxidative phosphorylationintermembrane spaceCardiomyocyteMoMMitochondriapyruvate kinasevoltage-dependent anion channelCreatine kinaseMitochondrial creatine kinase
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Authors
Tiia Anmann, Minna Varikmaa, Natalja Timohhina, Kersti Tepp, Igor Shevchuk, Vladimir Chekulayev, Valdur Saks, Tuuli Kaambre,