| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10795799 | Biochimica et Biophysica Acta (BBA) - Bioenergetics | 2013 | 10 Pages |
Abstract
⺠With 74 kDa mGPDH is the most simple component of mammalian respiratory chain. ⺠Highly tissue specific mGPDH forms glycerophosphate shuttle with cytosolic cGPDH. ⺠mGPDH connects glycolysis, fatty acid metabolism and oxidative phosphorylation. ⺠mGPDH is prone to electron leak and represents important site of ROS generation. ⺠Pathophysiological aspects of organ specific roles of mGPDH are discussed.
Keywords
mGPDHSDHCoQFFAOXPHOSG3PDAPBATROSΔψFree fatty acidbrown adipose tissueROS productionRETdihydroxyacetone phosphatesuccinate dehydrogenaseOxidative phosphorylationreverse electron transportPathophysiologyMitochondrial membrane potentialCoenzyme Qglycerol-3-phosphatemitochondrial glycerol-3-phosphate dehydrogenaseReactive oxygen species
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Authors
TomáÅ¡ MráÄek, ZdenÄk Drahota, Josef HouÅ¡tÄk,