Partitioning of superoxide and hydrogen peroxide production by mitochondrial respiratory complex I

Article ID	Journal	Published Year	Pages	File Type
10795823	Biochimica et Biophysica Acta (BBA) - Bioenergetics	2013	9 Pages	PDF

Abstract

âº Mammalian complex I generates both superoxide and hydrogen peroxide. âº Relative contribution of either species depends on NADH concentration. âº Guanidine stimulates complex I-mediated ROS production.

Keywords

Hexaammineruthenium(III)FMN DLDH Dihydrolipoamide dehydrogenase BSA ROS Hydrogen peroxide bovine serum albumin superoxide anion HAR SMP Submitochondrial particles SOD Superoxide dismutase flavin mononucleotide respiratory complex I pyridine nucleotides Horseradish peroxidase Guanidine Reactive oxygen species