Induction of the permeability transition pore in cells depleted of mitochondrial DNA

Article ID	Journal	Published Year	Pages	File Type
10795845	Biochimica et Biophysica Acta (BBA) - Bioenergetics	2012	7 Pages	PDF

Abstract

âº A mitochondrial (mt) permeability transition (PT) occurs in human 206 Ï0 cells. âº Detachment of mt hexokinase II is an effective PT trigger. âº A fraction of ERK1/2 and GSK3Î±/Î² is in the mt matrix of Ï0 cells. âº Glucose/serum deprivation (GSD) inhibits mt ERK and activates mt GSK3Î±/Î². âº PT plays a role in the death of 206 Ï0 cells by GSD.

Keywords

PTP FCCP ΔΨm GSK3β CyP-D TMRM EGTA Cyclophilin D Permeability transition pore Permeability transition Respiratory chain Cyclosporin tetramethylrhodamine methyl ester Mitochondrion hexokinase hexokinase II carbonylcyanide-p-trifluoromethoxyphenyl hydrazone