| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10795850 | Biochimica et Biophysica Acta (BBA) - Bioenergetics | 2012 | 6 Pages |
Abstract
⺠We determined the role of Trx2-, GSH-systems and catalase for H2O2 detoxification. ⺠The contribution of the Trx2- and GSH-systems was in rat brain 60 ± 20% and 20 ± 15%. ⺠The Trx2- and GSH-systems predominantly detoxify mitochondrially produced H2O2. ⺠Interneurons and microglia showed strong response to inhibition of Trx2-, GSH-systems. ⺠Pyramidal cells and astrocytes showed weak response to inhibition of Trx2-, GSH-systems.
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Authors
Alexei P. Kudin, BartÅomiej Augustynek, Anja Kerstin Lehmann, Richard Kovács, Wolfram S. Kunz,