| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10795867 | Biochimica et Biophysica Acta (BBA) - Bioenergetics | 2012 | 11 Pages |
Abstract
⺠The TPP+-tagged vitamin E succinate (MitoVES) affected mitochondrial functions. ⺠MitoVES stimulated basal respiration and ATP hydrolysis in mitochondria. ⺠MitoVES inhibited OxPhos and Ca2 + uptake by collapsing the membrane potential in mitochondria. ⺠The respiratory complex II was the most sensitive MitoVES target. ⺠MitoVes potently inhibited OxPhos and induced ATP depletion in rodent and human cancer cells.
Keywords
Related Topics
Life Sciences
Agricultural and Biological Sciences
Plant Science
Authors
Sara RodrÃguez-EnrÃquez, Luz Hernández-Esquivel, Alvaro MarÃn-Hernández, Lan-Feng Dong, Emmanuel T. Akporiaye, Jiri Neuzil, Stephen J. Ralph, Rafael Moreno-Sánchez,