| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10795939 | Biochimica et Biophysica Acta (BBA) - Bioenergetics | 2010 | 12 Pages |
Abstract
ⶠBAX self-integrates/oligomerizes in the OMM with miniscule cytochrome c release. ⶠCa2+ stimulates BAX insertion and cytochrome c release. ⶠCa2+ effect depends on induction of the mitochondrial permeability transition. ⶠBcl-xL does not prevent BAX insertion but attenuates cytochrome c release. ⶠDTT inhibits BAX insertion and the release of cytochrome c and Smac/DIABLO.
Keywords
BismaleimidohexaneNP-40EGSBcl-xLBMHOMMMPTCOX IVCytochrome oxidase subunit IV3-[(3-cholamidopropyl) dimethylammonio]-1-propanesulfonatesodium dodecyl sulfate-polyacrylamide gel electrophoresisSDS-PAGEPermeability transitionmitochondrial permeability transitionCSABaxtBidTriton X-100truncated Bidcyclosporin Aendoplasmic reticulumouter mitochondrial membraneMitochondriaBIDCHAPSCalciumOctyl glucoside
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Authors
Tatiana Brustovetsky, Tsyregma Li, Youyun Yang, Jiang-Ting Zhang, Bruno Antonsson, Nickolay Brustovetsky,