Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10795999 | Biochimica et Biophysica Acta (BBA) - Bioenergetics | 2009 | 6 Pages |
Abstract
Regulation of mitochondrial volume is a key issue in cellular pathophysiology. Mitochondrial volume and shape changes can occur following regulated fission-fusion events, which are modulated by a complex network of cytosolic and mitochondrial proteins; and through regulation of ion transport across the inner membrane. In this review we will cover mitochondrial volume homeostasis that depends on (i) monovalent cation transport across the inner membrane, a regulated process that couples electrophoretic K+ influx on K+ channels to K+ extrusion through the K+-H+ exchanger; (ii) the permeability transition, a loss of inner membrane permeability that may be instrumental in triggering cell death. Specific emphasis will be placed on molecular advances on the nature of the transport protein(s) involved, and/or on diseases that depend on mitochondrial volume dysregulation.
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Authors
Karin Nowikovsky, Rudolf J. Schweyen, Paolo Bernardi,