Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10796067 | Biochimica et Biophysica Acta (BBA) - Bioenergetics | 2005 | 4 Pages |
Abstract
The introduction of a primary amine function on the terminal α,β-unsaturated lactone of squamocin 1, a common structural hallmark of annonaceous acetogenins, shifted this specific inhibitor of mitochondrial complex I into a potent dual inhibitor of complexes I and III. The mechanism of action of β-aminosquamocin 2, against these two respiratory targets, is studied and discussed in view of current structure-activity relationship knowledge in the acetogenin series.
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Authors
Romain A. Duval, Erwan Poupon, Ulrich Brandt, Reynald Hocquemiller,