| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10814769 | Cellular Signalling | 2016 | 32 Pages |
Abstract
In human lung fibroblasts, PDGF-BB stimulation activates ERK1/2 MAPK signaling, which induces the phosphorylation of STAT1. P-STAT1 is essential for PRMT1 upregulation which orchestrates fibroblast proliferation and ECM production. Therefore, PRMT1 may play a crucial role in fibrotic processes and presents a novel therapeutic target in chronic inflammatory pulmonary diseases.165
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Authors
Qingzhu Sun, Li Liu, Jyotshna Mandal, Antonio Molino, Daiana Stolz, Michael Tamm, Shemin Lu, Michael Roth,