| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10824155 | Insect Biochemistry and Molecular Biology | 2012 | 11 Pages |
Abstract
⺠Manduca sexta Toll interacts with MsSpz-C108 (the active C-terminal domain of Spz) but not with full-length MsSpz. ⺠Co-expression of MsToll with MsSpz-C108 but not MsSpz activates drosomycin in Drosophila S2 cells. ⺠Activation of AMP genes in M. sexta larvae by MsSpz-C108 is blocked by antibody to MsToll. ⺠Activation of M. sexta AMP genes by Lys-type and DAP-type peptidoglycans is blocked by antibody to MsToll. ⺠Both in vitro and in vivo results demonstrate a Toll-Spz pathway in M. sexta, a lepidopteran insect.
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Authors
Xue Zhong, Xiao-Xia Xu, Hui-Yu Yi, Christopher Lin, Xiao-Qiang Yu,