| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10824206 | Insect Biochemistry and Molecular Biology | 2012 | 10 Pages |
Abstract
⺠Haemaphysalis longicornis chymotrypsin inhibitor, HlChI, was expressed and localized in the cytoplasm of the hemocytes of the ticks. ⺠HlChI potently inhibited bovine α-chymotrypsin but weakly inhibited bovine trypsin and could not inhibit porcine elastase. ⺠HlChI was stable over the pH range 2-11 and heating up to 70 °C at pH 8.0. ⺠HlChI gene knockdown caused disruption of feeding, death of feeding ticks and impacted markedly on reproduction of ticks. ⺠HlChI might be a promising candidate for therapeutic agent/vaccine development for controlling ticks and tick borne diseases.
Related Topics
Life Sciences
Agricultural and Biological Sciences
Insect Science
Authors
M. Abdul Alim, M. Khyrul Islam, Anisuzzaman Anisuzzaman, Takeharu Miyoshi, Takeshi Hatta, Kayoko Yamaji, Makoto Matsubayashi, Kozo Fujisaki, Naotoshi Tsuji,