Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10837493 | Pesticide Biochemistry and Physiology | 2005 | 8 Pages |
Abstract
Functional brain alterations induced by lindane were examined in Rat chronically exposed to low doses of lindane (1 and 2 μg Lâ1 in drinking water) from conception. Histological and electrophysiological investigations were conducted at 14 weeks of age. Lindane did not induce histological changes. It did not significantly modify the sleep-wakefulness cycle and EEG did not show major alterations. The spectral EEG analysis, by recording cortical variations in both energy spectrum and energy levels of different frequency bands, showed an increase in the 11-15 Hz activity in both groups exposed to lindane. This activity was characterised by spindles well-depicted during slow wave sleep or associated with fast activity during wakefulness and theta activity in paradoxical sleep. These data suggest that chronic exposure to lindane doses as low as 1 μg Lâ1 in drinking water could lead to central electrophysiological effects possibly involving GABA-benzodiazepine mechanisms.
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Authors
P. Breton, S. Bouvet, I. Delamanche, J. Buée, F. Goudey Perrière, N. Pagès,