Autophagy and proteins involved in vesicular trafficking

Article ID	Journal	Published Year	Pages	File Type
10869825	FEBS Letters	2015	11 Pages	PDF

Abstract

Autophagy is an intracellular degradation system that, as a basic mechanism it delivers cytoplasmic components to the lysosomes in order to maintain adequate energy levels and cellular homeostasis. This complex cellular process is activated by low cellular nutrient levels and other stress situations such as low ATP levels, the accumulation of damaged proteins or organelles, or pathogen invasion. Autophagy as a multistep process involves vesicular transport events leading to tethering and fusion of autophagic vesicles with several intracellular compartments. This review summarizes our current understanding of the autophagic pathway with emphasis in the trafficking machinery (i.e. Rabs GTPases and SNAP receptors (SNAREs)) involved in specific steps of the pathway.

Keywords

SQSTM1 AMD pKa Rab GTPase SNARE ATG LC3 EREs sequestosome 1 phagophore assembly site VPS FIP200 FYCO1 NS4B MVB STX GEF ULK1 CMA AMPK EGF Leucine-rich repeat kinase 1 GTP Dfcp1 PtdIns3P coat protein complex II LRRK1 WIPI TRAPP mTOR Endoplasmic reticulum exit sites Guanosine nucleotide exchange factor PIK3C3 NSF AMP-activated protein kinase Chaperone-mediated autophagy GTPase Activating Protein unc-51 like autophagy activating kinase 1 recycling endosome Autophagy multivesicular body Huntington disease GDP light chain 3 syntaxin endoplasmic reticulum GAP SNAP epidermal growth factor phosphatidylethanolamine phosphatidylinositol 3-phosphate Vacuolar protein sorting PAS Mechanistic target of rapamycin Hepatitis C virus HCV Molecular weight transport protein particle autophagy-related protein cAMP-dependent protein kinase COPII Gas Group A Streptococcus Guanosine triphosphate guanosine diphosphate SNAP Receptor