| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10869902 | FEBS Letters | 2015 | 9 Pages |
Abstract
The transcription factor estrogen receptor β (ERβ) plays roles in the central nervous, endocrine, cardiovascular, and immune systems. ERβ can be SUMOylated. However, the underlying mechanism remains unclear. Here, we show that RSRC1/SRrp53 interacts with ERβ and SUMOylation of RSRC1 is required for regulation of PIAS1-mediated ERβ SUMOylation. RSRC1 promotes ERβ SUMOylation through enhanced interaction between ERβ and PIAS1. RSRC1 represses ERβ transcriptional activity through regulation of ERβ SUMOylation. By establishing RSRC1 as a novel cofactor for SUMOylation, our data provide insight into regulation of ERβ SUMOylation and indicate that SUMOylation of one protein can regulate another protein SUMOylation.
Related Topics
Life Sciences
Agricultural and Biological Sciences
Plant Science
Authors
Lihan Chen, Weini Li, Weiyi Qiu, Wen Ren, Qincao Li, Baiyu Han, Lei Zhou, Long Cheng, Hao Zhang, Qinong Ye,