| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10869903 | FEBS Letters | 2015 | 6 Pages |
Abstract
MicroRNAs (miRNAs) play a significant role in tumor development. Recent studies indicate that miRNAs are implicated in prostate cancer (PCa). In this study, we found that miR-19a expression was significantly increased in castration-resistant prostate cancer (CRPC) tissues compared with androgen-dependent prostate cancer (ADPC) tissues. We found that inhibiting the overexpression of miR-19a in CRPC cells suppressed proliferation and increased apoptosis. Additionally, we found that miR-19a repressed BTG1 expression by binding to its 3â²-untranslated region. The overexpression of BTG1 in CRPC cells significantly suppressed proliferation and increased apoptosis. We conclude that miR-19a regulates proliferation and apoptosis of CRPC cells by directly targeting the tumor suppressor gene BTG1.
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Authors
Kai Lu, Chunhui Liu, Tao Tao, Xiaowen Zhang, Lei Zhang, Chao Sun, Yiduo Wang, Shuqiu Chen, Bin Xu, Ming Chen,