Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10869925 | FEBS Letters | 2015 | 9 Pages |
Abstract
Our understanding of how metabolic switches occur in the failing heart is still limited. Here, we report the emblematic pattern of metabolic alternations in two different mouse models. PP2Acα deficient hearts exhibited a dramatic decrease in the levels of mRNA encoding for transporters and enzymes involved in glucose utilization, which compensated by higher expression levels of genes controlling fatty acid utilization. These features were partly reproduced in cultured PP2Acα KD cardiomyocytes. Equivalently, a decrease in the expression of most of the transporters and enzymes controlling both glucose and fatty acid metabolism were observed in TAC model.
Keywords
CPTACSL1ACADSPFKMLVIDACADVLHK2PDHBPKM2PDKFABPACADMIDHLVMANPHDLGLUTCD36BNPfatty acid translocaseMyocardial energeticsIsocitrate dehydrogenase 1triglycerideLeft ventricular massCitrate synthasePhosphofructokinaseleft ventricular internal diameterLDLheart failureFatty acid binding proteinprotein phosphatase 2ATranscriptional profilingbrain natriuretic peptideatrial natriuretic peptidePyruvate dehydrogenase kinaseCarnitine palmitoyltransferaseejection fractiontotal cholesterolfractional shortening
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Authors
Dachuan Dong, Liangyuan Li, Pengyu Gu, Tao Jin, Mingda Wen, Caihua Yuan, Xiang Gao, Chang Liu, Zhao Zhang,