Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10869980 | FEBS Letters | 2015 | 8 Pages |
Abstract
GGPPS catalyses the expression of GGPP, a key protein in the mevalonate metabolic pathway. HMG-CoA reductase inhibitor statins can induce liver injury by inhibiting GGPP. However, the function of GGPPS in liver injury has not yet been revealed. In this study, we found that GGPPS increased in liver injury and that GGPPS deletion augmented liver injury and fibrosis. GGPPS inhibition induced hepatocyte apoptosis, inflammation and TGF-β1 secretion, which activated hepatic stellate cells. Our findings imply that GGPPS deletion induces hepatocyte apoptosis, which makes the liver vulnerable to hepatotoxicity.
Keywords
ECMGGPPSPCNAPIPCCOL1A1GGPPPDGFHMG-CoAPARPCCl4CTGFGAPDHshRNAα-SMAFPPHSCFBSTGF-β1HCCMAPKshort hairpin RNALiver injuryProliferating Cell Nuclear AntigenHepatocyte apoptosisNon-alcoholic steatohepatitisα-smooth muscle actinTransforming growth factor-beta 1tumour necrosis factor-alphafoetal bovine serumHepatic stellate cellsfarnesyl pyrophosphateConnective tissue growth factorplatelet-derived growth factorTNF-αLiver fibrosisExtracellular matrixNash wild typeHCVHepatitis C virusmitogen-activated protein kinasepoly ADP-ribose polymerasegeranylgeranyl pyrophosphateHepatocellular carcinomaCarbon tetrachlorideType I collagenGeranylgeranyl diphosphate synthaseglyceraldehyde-3-phosphate dehydrogenase
Related Topics
Life Sciences
Agricultural and Biological Sciences
Plant Science
Authors
Wei-Bo Chen, Shan-Shan Lai, De-Cai Yu, Jia Liu, Shan Jiang, Dan-Dan Zhao, Yi-Tao Ding, Chao-Jun Li, Bin Xue,