Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10869981 | FEBS Letters | 2015 | 25 Pages |
Abstract
MicroRNAs have been reported to play critical roles in various cancers, but there has been no study on the role of miR-889 in cancers. Here, we report that over-expression of miR-889 leads to rapid proliferation of EC109 and EC9706 cells in vitro and in vivo by inducing cells into S-phase. Using bioinformatics methods, DAB2IP was further confirmed to be a direct target of miR-889. In addition, the expression of DAB2IP, which was negatively correlated with that of miR-889, was significantly associated with clinicopathological features of ESCC patients. In conclusion, miR-889 is an important regulator in ESCC and both miR-889 and DAB2IP may serve as promising biomarkers and therapeutic targets in patients with ESCC.
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Authors
Yanting Xu, Jiangtu He, Yue Wang, Xinyi Zhu, Qiuhui Pan, Qiuling Xie, Fenyong Sun,