Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10870032 | FEBS Letters | 2014 | 9 Pages |
Abstract
Chronic hypoxia triggers pulmonary vascular remodeling, which is associated with de-differentiation of pulmonary artery smooth muscle cells (PASMC). Here, we show that miR-20a expression is up-regulated in response to hypoxia in both mouse and human PASMC. We also observed that miR-20a represses the protein kinase, cGMP-dependent, type I (PRKG1) gene and we identified two crucial miR-20a binding sites within the coding region of PRKG1. Functional studies showed that miR-20a promotes the proliferation and migration of human PASMC, whereas it inhibits their differentiation. In summary, we provided a possible mechanism by which hypoxia results in decreased PRKG1 expression and in the phenotypic switching of PASMC.
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Authors
Yan Zeng, Yanping Pan, Hongtai Liu, Kang Kang, Yike Wu, Gang Hui, Wenda Peng, Ramaswamy Ramchandran, J. Usha Raj, Deming Gou,