Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10870081 | FEBS Letters | 2015 | 7 Pages |
Abstract
STAT3 is associated with embryo development and survival as well as proliferation and metastasis of tumor cells. In a previous study, we demonstrated that STAT3-Interacting Protein As a Repressor (SIPAR) enhances the dephosphorylation of STAT3 and negatively regulates its activity. However, it remains unclear how SIPAR inhibits phosphorylation of STAT3. Here we demonstrate that SIPAR directly interacts with T cell protein tyrosine phosphatase TC45 and enhances its association with STAT3. This interaction triggers an accelerated dephosphorylation process for STAT3. Furthermore, SIPAR inhibits the transcriptional activity of STAT3 in wild-type MEF cells but not in TC45 null MEF cells. These results suggest that SIPAR terminates the activation of STAT3 through a dephosphorylation process that is dependent upon interaction with TC45 in the nucleus.
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Authors
Fangli Ren, Yongtao Geng, Takayuki Minami, Ying Qiu, Yarui Feng, Chunxiao Liu, Juan Zhao, Yinyin Wang, Xuanzi Fan, Yangmeng Wang, Mengdi Li, Jun Li, Zhijie Chang,