Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10870123 | FEBS Letters | 2014 | 6 Pages |
Abstract
To maintain a quiescent gut microenvironment, proper regulation of immune responses initiated by pro-inflammatory immune subsets is required. Several types of regulatory T cells are reported to exert pivotal roles in achieving this. Among various types of regulatory T cells, the crucial role of Foxp3+ Treg cells has been well documented. Furthermore, accumulating evidence demonstrates that both microbial and dietary factors influence the induction and suppressor functions of intestinal Foxp3+ Treg cells. Foxp3+ Treg cells are a highly activated T cell subset which responds rapidly to environmental and nutritional stimuli. Thus, sufficient nutrient supply is required to fuel the high energetic status of Foxp3+ Treg cells for the regulation of intestinal immunity.
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Authors
Makoto Kinoshita, Kiyoshi Takeda,