Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10870159 | FEBS Letters | 2014 | 8 Pages |
Abstract
Although decidualization is crucial for the establishment of successful pregnancy, the molecular mechanism underlying decidualization remains poorly understood. Crystallin αB (CryAB), a small heat shock protein (sHSP), is up-regulated and phosphorylated in mouse decidua. In mouse primary endometrial stromal cells, CryAB is induced upon progesterone treatment via HIF1α. In addition, CryAB is strongly phosphorylated through the p38-MAPK pathway under stress or during in vitro decidualization. Knockdown of CryAB results in the increase of apoptosis of stromal cells and inhibits decidualization under oxidative or inflammatory stress. Our data indicate that CryAB protects decidualization against stress conditions.
Keywords
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Plant Science
Authors
Ru-Juan Zuo, Yue-Chao Zhao, Wei Lei, Tong-Song Wang, Bao-Cheng Wang, Zeng-Ming Yang,