Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10870189 | FEBS Letters | 2014 | 10 Pages |
Abstract
PPP2R5E belongs to the phosphatase 2A regulatory subunit B family and acts as a tumor suppressor in human cancer. However, the role of PPP2R5E in the tumorigenesis of gastric cancer is unclear. Here, we declare that PPP2R5E is downregulated by miR-23a and induces cell growth inhibition and apoptosis in gastric cancer cells. Furthermore, ASO-miR-23a suppresses tumor growth derived from MGC803 cells in vivo. PPP2R5E is identified as a new target of miR-23a. Moreover, overexpression of PPP2R5E reversed the negative effects of miR-23a. We highlight the significance of miR-23a and PPP2R5E in the proliferation and apoptosis of gastric cancer cells.
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Authors
Xue Liu, Qian Liu, Yajie Fan, Shaohua Wang, Xinrui Liu, Lihua Zhu, Min Liu, Hua Tang,