| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10870232 | FEBS Letters | 2014 | 15 Pages |
Abstract
The ING (inhibitor of growth) proteins (ING1-ING5) have emerged as a versatile family of growth regulators, phospholipid effectors, histone mark sensors and core components of HDAC1/2 - and several HAT chromatin-modifying complexes. This review will describe the characteristic pathways by which ING family proteins differentially affect the Hallmarks of Cancer and highlight the various epigenetic mechanisms by which they regulate gene expression. Finally, we will discuss their potentials as biomarkers and therapeutic targets in epigenetic treatment strategies.
Keywords
CDKPCNASUMOTGFβIngHDACH3K4me3MGMTNFkBPHDDnmtDNA methyltransferaseDNAsiRNAproliferating-cell nuclear antigendesoxyribonucleic acidsmall interfering ribonucleic acidInhibitor of growthTransforming Growth Factor Betabase pairTumor suppressionnuclear factor kappa BPhosphatidylinositol 5-phosphateEpigenetic regulationHistoneHistone acetyltransferasehistone deacetylaseHATsmall ubiquitin-like modifiercyclin-dependent kinaseplant homeodomain
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Authors
Gesche Tallen, Karl Riabowol,