Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10870275 | FEBS Letters | 2015 | 5 Pages |
Abstract
We identified a yeast mutant with temperature-sensitive growth defects that were rescued by VCP expression. The mutation occurred in GPI10, which encodes a mannosyl transferase for glycosylphosphatidylinositol anchor formation in the endoplasmic reticulum, and caused a Gly469Glu substitution in Gpi10. The mutant exhibited increased unfolded protein response, which was partially rescued by VCP or Cdc48, and showed sensitivity against cell-wall stressors, which were not rescued by VCP. These results suggest a potential link between VCP/Cdc48 and Gpi10 functions in the control of cell growth.
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Authors
Yohei Ohnuma, Takahiro Takata, Junko Kawawaki, Kunihiko Yasuda, Keiji Tanaka, Yoko Kimura, Akira Kakizuka,