| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10870429 | FEBS Letters | 2014 | 10 Pages |
Abstract
The aberrant expression of PSMD10 has important functions in various malignancies. This study showed that PSMD10 was highly expressed and inversely correlated with the expression of miR-605 in intrahepatic cholangiocarcinoma (ICC) specimens. MiR-605 directly targeted and repressed PSMD10 expression. In addition, over-expression of miR-605 inhibited ICC cell progression both in vitro and in vivo. This effect of miR-605 on ICC cells was similar to that of PSMD10 knock-down by RNAi. Moreover, restoration of PSMD10 could reverse the phenotypic alteration caused by miR-605 in ICC cells. These results suggest a new therapeutic strategy in ICC by restoring miR-605, which is regulated by p53.
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Authors
Jianwei Li, Feng Tian, Dajiang Li, Jian Chen, Peng Jiang, Shuguo Zheng, Xiaowu Li, Shuguang Wang,