| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10870455 | FEBS Letters | 2015 | 8 Pages |
Abstract
Mesenchymal stem cells (MSCs) play an important role in the pathology of preeclampsia (PE). Our previous microarray analysis found that microRNA-494 (miR-494) is highly expressed in decidua-derived MSCs (dMSCs) from PE. We hypothesized that aberrant expression of miR-494 in dMSCs is involved in PE development. In the present study, we found that miR-494 arrests G1/S transition in dMSCs by targeting CDK6 and CCND1. We also found that supernatant from miR-494-overexpressing dMSCs reduces HTR-8/SVneo migration and impairs HUVEC capillary formation by suppressing VEGF. Taken together, we report an unrecognized mechanism of miR-494 affecting dMSC proliferation and function in the pathology of PE.
Keywords
Cyclin E1IL-6CCNE1Cyclin D2si-RNAMSCsMCP-1miR-494CCND1IVF-ETCyclin D1HELLPCCND2Cdk6Small interfering RNAAngiogenesisinterleukin-6microRNAsMesenchymal stem cellMesenchymal stem cellsVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)in vitro fertilization and embryo transfermonocyte chemoattractant protein-1Preeclampsia
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Authors
Shiwen Chen, Guangfeng Zhao, Huishuang Miao, Ruijing Tang, Yuxian Song, Yali Hu, Zhiqun Wang, Yayi Hou,