Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10870472 | FEBS Letters | 2014 | 8 Pages |
Abstract
This study aimed to test the exact functions and potential mechanisms of miR-17-5p in gastric cancer. Using real-time PCR, miR-17-5p was found to be expressed more highly in gastric cancer compared with-normal tissues. Gain- and loss-of-function assays demonstrated that miR-17-5p increased the proliferation and growth of gastric cancer cells in vitro and in vivo. Through reporter gene and western blot assays, SOCS6 was shown to be a direct target of miR-17-5p, and proliferative assays confirmed that SOCS6 exerted opposing function to that of miR-17-5p in gastric cancer. In short, miR-17-5p might function as a pro-proliferative factor by repressing SOCS6 in gastric cancer.
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Authors
Qiong Wu, Guanhong Luo, Zhiping Yang, Fei Zhu, Yanxin An, Yongquan Shi, Daiming Fan,