Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10870498 | FEBS Letters | 2014 | 6 Pages |
Abstract
RBM10, originally called S1-1, is a nuclear RNA-binding protein with domains characteristic of RNA processing proteins. It has been reported that RBM10 constitutes spliceosome complexes and that RBM5, a close homologue of RBM10, regulates alternative splicing of apoptosis-related genes, Fas and cFLIP. In this study, we examined whether RBM10 has a regulatory function in splicing similar to RBM5, and determined that it indeed regulates alternative splicing of Fas and Bcl-x genes. RBM10 promotes exon skipping of Fas pre-mRNA as well as selection of an internal 5â²-splice site in Bcl-x pre-mRNA. We propose a consensus RBM10-binding sequence at 5â²-splice sites of target exons and a mechanistic model of RBM10 action in the alternative splicing.
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Authors
Akira Inoue, Naoki Yamamoto, Masatsugu Kimura, Koji Nishio, Hideo Yamane, Koichi Nakajima,