| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10870526 | FEBS Letters | 2015 | 9 Pages |
Abstract
Low-intensity pulsed ultrasound (LIPUS) is used for bone healing in orthopedics and dentistry. It has been shown that LIPUS induces the secretion of extracellular adenosine triphosphate (ATP), a key mediator of osteoblast response to mechanical stimuli. However, the detailed mechanism of LIPUS-induced osteogenesis has been elusive. In this study, we investigated the role of the P2X7 receptor in LIPUS-induced osteogenesis. LIPUS induced the release of extracellular ATP, differentiation of osteoblasts and osteogenesis via the P2X7 receptor, without affecting the activity of alkaline phosphatase (ALPase). These results suggest that LIPUS-induced extracellular ATP promotes bone formation via the osteoblast P2X7 receptor independently of ALPase.
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Authors
Soichiro Manaka, Natsuko Tanabe, Taro Kariya, Masako Naito, Tadahiro Takayama, Mayu Nagao, Di Liu, Koichi Ito, Masao Maeno, Naoto Suzuki, Masashi Miyazaki,