Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10870533 | FEBS Letters | 2015 | 10 Pages |
Abstract
Formation of tubulin/Na+,K+-ATPase (NKA) complex in erythrocytes of hypertensive subjects results in a 50% reduction in NKA activity. We demonstrate here that detyrosinated tubulin, which is increased in hypertensive erythrocytes membranes, enhances the inhibitory effect of acetylated tubulin on NKA activity. Moreover, we report a reduced content and activity of the enzyme tubulin tyrosine ligase in erythrocytes of hypertensive subjects. Such alterations are related to changes in erythrocyte deformability. Our findings indicate that the detyrosination/tyrosination cycle of tubulin is important in regulation of NKA activity, and that abnormalities in this cycle are involved in hypertension development.
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Authors
Marina R. Amaiden, VerĂ³nica S. Santander, Noelia E. Monesterolo, Ayelen D. Nigra, Juan F. Rivelli, Alexis N. Campetelli, Juan Pie, Cesar H. Casale,