Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10870570 | FEBS Letters | 2014 | 7 Pages |
Abstract
End-binding protein (EB1) is a microtubule protein that binds to the tumor suppressor adenomatous polyposis coli (APC). While EB1 is implicated as a potential oncogene, its role in cancer progression is unknown. Therefore, we analyzed EB1/APC expression at the earliest stages of colorectal carcinogenesis and in the uninvolved mucosa (“field effect”) of human and animal tissue. We also performed siRNA-knockdown in colon cancer cell lines. EB1 is up-regulated in early and field carcinogenesis in the colon, and the cellular/nano-architectural effect of EB1 knockdown depended on the genetic context. Thus, dysregulation of EB1 is an important early event in colon carcinogenesis.
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Authors
Yolanda Stypula-Cyrus, Nikhil N. Mutyal, Mart Dela Cruz, Dhananjay P. Kunte, Andrew J. Radosevich, Ramesh Wali, Hemant K. Roy, Vadim Backman,