Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10870610 | FEBS Letters | 2014 | 7 Pages |
Abstract
The leader protease (Lpro) from foot-and-mouth disease virus (FMDV) has the ability to cleave eIF4G, leading to a blockade of cellular protein synthesis. In contrast to previous reports, our present findings demonstrate that FMDV Lpro is able to increase translation driven by FMDV IRES. Additionally, inactivation of eIF2 subsequent to phosphorylation induced by arsenite or thapsigargin in BHK cells blocks protein synthesis directed by FMDV IRES, whereas in the presence of Lpro, significant translation is found under these conditions. This phenomenon was also observed in cell-free systems after induction of eIF2 phosphorylation by addition of poly(I:C).
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Authors
Pablo Moral-López, Enrique Alvarez, Natalia Redondo, Tim Skern, Luis Carrasco,