Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10870625 | FEBS Letters | 2014 | 6 Pages |
Abstract
Isolated atrial amyloidosis (IAA) is a common localized form of amyloid deposition within the atria of the aging heart. The main constituents of amyloid fibrils are atrial natriuretic peptide (ANP) and the N-terminal part of its precursor form (NT-proANP). An 'aggregation-prone' heptapeptide (114KLRALLT120) was located within the NT-proANP sequence. This peptide self-assembles into amyloid-like fibrils in vitro, as electron microscopy, X-ray fiber diffraction, ATR FT-IR spectroscopy and Congo red staining studies reveal. Consequently, remedies/drugs designed to inhibit the aggregation tendency of this 'aggregation-prone' segment of NT-proANP may assist in prevention/treatment of IAA, congestive heart failure (CHF) or atrial fibrillation (AF).
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Authors
Nikolaos N. Louros, Vassiliki A. Iconomidou, Paraskevi L. Tsiolaki, Evangelia D. Chrysina, Georgios E. Baltatzis, Efstratios S. Patsouris, Stavros J. Hamodrakas,