Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10870636 | FEBS Letters | 2014 | 7 Pages |
Abstract
MicroRNAs are a class of small, endogenous, non-coding RNAs that function as post-transcriptional regulators. In this study, we found that miR-181b promoted cell proliferation and inhibited cell apoptosis in cervical cancer cells. And we validated a new miR-181b target gene, adenylyl cyclase 9 (AC9). miR-181b restricted cAMP production by post-transcriptionally downregulating AC9 expression. Phenotypic experiments indicated that miR-181b and AC9 exerted opposite effects on cell proliferation and apoptosis.
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Authors
Lei Yang, Yan-Li Wang, Shang Liu, Pei-Pei Zhang, Zheng Chen, Min Liu, Hua Tang,