Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10870676 | FEBS Letters | 2014 | 9 Pages |
Abstract
Connexin proteins are short-lived within the cell, whether present in the secretory pathway or in gap junction plaques. Their levels can be modulated by their rate of degradation. Connexins, at different stages of assembly, are degraded through the proteasomal, endo-/lysosomal, and phago-/lysosomal pathways. In this review, we summarize the current knowledge about connexin and gap junction degradation including the signals and protein-protein interactions that participate in their targeting for degradation.
Related Topics
Life Sciences
Agricultural and Biological Sciences
Plant Science
Authors
Matthias M. Falk, Rachael M. Kells, Viviana M. Berthoud,