| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10870787 | FEBS Letters | 2013 | 7 Pages |
Abstract
Screening for suppressors of canthin-6-one toxicity in yeast identified Yap1, a transcription factor involved in cell response to a broad range of injuries. Although canthin-6-one did not promote a significant oxidative stress, overexpression of YAP1 gene clearly increased resistance to this drug. We demonstrated that Yap1-mediated resistance involves the plasma membrane major-facilitator-superfamily efflux pump Flr1 but not the vacuolar ATP-binding-cassette transporter Ycf1. FLR1 overexpression was sufficient to reduce sensitivity to the drug, but strictly dependent on a functional YAP1 gene.
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Authors
Camille Dejos, Matthieu Régnacq, Marianne Bernard, Pierre Voisin, Thierry Bergès,