Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10870789 | FEBS Letters | 2013 | 5 Pages |
Abstract
Hepatitis B x antigen up-regulates the liver expression of URG7 that contributes to sustain chronic virus infection and to increase the risk for hepatocellular carcinoma by its anti-apoptotic activity. We have investigated the subcellular localization of URG7 expressed in HepG2 cells and determined its membrane topology by glycosylation mapping in vitro. The results demonstrate that URG7 is N-glycosylated and located to the endoplasmic reticulum membrane with an Nlumen-Ccytosol orientation. The results imply that the anti-apoptotic effect of URG7 could arise from the C-terminal cytosolic tail binding a pro-apoptotic signaling factor and retaining it to the endoplasmic reticulum membrane.
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Authors
A. Ostuni, P. Lara, M.F. Armentano, R. Miglionico, A.M. Salvia, M. Mönnich, M. Carmosino, F.M. Lasorsa, M. Monné, I. Nilsson, F. Bisaccia,