| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10870801 | FEBS Letters | 2013 | 7 Pages |
Abstract
We found that exposure of PC12 cells to ASN increases Cdk5 activity via calpain-dependent p25 formation and by enhancement of Cdk5 phosphorylation at Tyr15. Cdk5 and calpain inhibitors prevented ASN-evoked cell death. Our findings, indicating the participation of Cdk5 in ASN toxicity, provide new insight into how extracellular ASN may trigger dopaminergic cell dysfunction in PD.
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Authors
Grzegorz A. Czapski, Magdalena GÄ
ssowska, Anna Wilkaniec, Magdalena CieÅlik, Agata Adamczyk,