Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10870821 | FEBS Letters | 2013 | 4 Pages |
Abstract
Up to 15% of the genes in different genomes overlap. This architecture, although beneficial for the genome size, represents an obstacle for simultaneous transcription of both genes. Here we analyze the interference between RNA-polymerase II (Pol II) and RNA-polymerase III (Pol III) when transcribing their target genes encoded on opposing strands within the same DNA fragment in Arabidopsis thaliana. The expression of a Pol II-dependent protein-coding gene negatively correlated with the transcription of a Pol III-dependent, tRNA-coding gene set. We suggest that the architecture of the overlapping genes introduces an additional layer of control of gene expression.
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Authors
Radoslaw Lukoszek, Bernd Mueller-Roeber, Zoya Ignatova,