| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10870829 | FEBS Letters | 2013 | 7 Pages |
Abstract
The membrane-bound Vanin-1 pantetheinase regulates tissue adaptation to stress. We investigated Vnn1 expression and its regulation in liver. Vnn1 is expressed by centrolobular hepatocytes. Using novel tools, we identify a soluble form of Vnn1 in mouse and human serum and show the contribution of a cysteine to its catalytic activity. We show that liver contributes to Vanin-1 secretion in serum and that PPARalpha is a limiting factor in serum Vnn1 production. Functional PPRE sites are identified in the Vnn1 promoter. These results indicate that serum Vnn1 might be a reliable reporter of PPARalpha activity in liver.
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Authors
Samuel Rommelaere, Virginie Millet, Thomas Gensollen, Christophe Bourges, Jérôme Eeckhoute, Nathalie Hennuyer, Eric Baugé, Lionel Chasson, Ivana Cacciatore, Bart Staels, Giuseppina Pitari, Franck Galland, Philippe Naquet,