Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10870902 | FEBS Letters | 2013 | 7 Pages |
Abstract
To identify potential biomarkers associated with Alzheimer's disease (AD)-like neuropathologies in the murine brain, we conducted proteomic analyses of neocortices from TgCRND8 mice. Here we found that phosphoprotein enriched in astrocytes 15Â kDa (PEA-15) is expressed at higher levels in the neocortical proteomes from 6-month old TgCRND8 mice, as compared to non-transgenic mice. Immunostaining for PEA-15 revealed reactive astrocytes associated with the neocortical amyloid plaques in TgCRND8 mice and in post-mortem human AD brains. This is the first report of increased phosphoprotein enriched in astrocytes (PEA-15) expression in reactive astrocytes of an AD mouse model and human AD brains.
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Authors
Lynsie A.M. Thomason, Laura J. Smithson, Lili-Naz Hazrati, JoAnne McLaurin, Michael D. Kawaja,