| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10870941 | FEBS Letters | 2013 | 5 Pages |
Abstract
TIMP-1, a well-known MMP inhibitor, displays other biological activities such as cell survival, proliferation and differentiation in hematopoietic cells. In this report, we investigated the role of the Src-related kinase Lyn in TIMP-1 induced UT-7 erythroleukemic cell survival. We showed that (i) tyrosine 507 of Lyn was dephosphorylated and Lyn kinase activity enhanced by TIMP-1, (ii) Lyn silencing suppressed TIMP-1 anti-apoptotic activity and (iii) Lyn was activated upstream the JAK2/PI 3-kinase/Akt pathway. Our data suggest a novel role for Lyn in erythroid cell survival.
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Authors
Lucie Bridoux, Nicolas Etique, Elise Lambert, Jessica Thevenard, Marie-Line Sowa, Nicolas Belloy, Manuel Dauchez, Laurent Martiny, Emmanuelle Charpentier,